A Benign form of HbE/ Beta-Thalassemia
نویسندگان
چکیده
منابع مشابه
Why are hemoglobin F levels increased in HbE/beta thalassemia?
To try to further define the mechanisms that increase the levels of hemoglobin F (HbF) in the blood of patients with severe forms of beta thalassemia, we have studied two comparable populations of hemoglobin E (HbE)/beta thalassemics, one regularly transfused and one receiving only occasional blood transfusions. Regular transfusion was associated with a significant decrease in soluble transferr...
متن کاملRole of interleukin-3 and signaling pathways on beta-thalassemia/HbE erythroid progenitor cell in culture.
In order to study the role of the cytokine interleukin-3 (IL-3) and its signaling pathways in erythropoiesis of beta-thalassemia/HbE erythroid progenitor cells, CD34 positive cells were isolated from peripheral blood of patients and healthy subjects. After culturing the cells in the presence or absence of IL-3, cell viability was measured by trypan blue staining and apoptotic cells were analyze...
متن کاملFactors Associated in Production of Raised Gama Globin Chain in HbE/ β-Thalassemia – A Review
HbE/β-thalassaemia genotype represent approximately 50% of all severe β-thalassemia worldwide and is the commonest form of thalassemia in many Asian countries, predominantly prevalent in North-Eastern region exhibiting phenotypes that range from severely symptomatic and transfusion-dependent anaemia in early life to a asymptomatic and clinically ‘silent’ condition that is ascertained by chance ...
متن کاملThalassemia intermedia resulting from a mild beta-thalassemia mutation.
We investigated the molecular basis for a mild phenotype in a group of patients with beta(+) thalassemia originating from Northern Sardinia by definition of the beta-thalassemia mutation, alpha-globin mapping and beta-globin haplotype determination. In nine patients, we detected the compound heterozygous state for the -87 promoter mutation and the codon 39 nonsense mutation; in one patient, we ...
متن کاملMalignancies in patients with beta-thalassemia major and beta-thalassemia intermedia: a multicenter study in Iran.
BACKGROUND Beta thalassemia is one of the most common genetic disorders in the world. The aim of this study was to determine the frequency, characteristics, and pattern of malignancies in patients with beta thalassemia major (BTM) and beta thalassemia intermedia (BTI) in Iran. METHODS We conducted a multicenter study via a retrospective chart review of patients with BTM and BTI between 2002 a...
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ژورنال
عنوان ژورنال: Journal of Hematological Malignancies
سال: 2012
ISSN: 1925-4032,1925-4024
DOI: 10.5430/jhm.v2n1p37